' 
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
7
Zinc levels and MS correlation
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Highly relevant to MS treatment
We conducted a study to understand how zinc may affect multiple sclerosis (MS). Our research involved 98 participants, divided into two groups: one with MS and another matched control group without the condition. We aimed to examine the levels of zinc in both plasma and red blood cells to see if there’s a connection with MS severity and outbreaks.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
Read More
9
Zinc supplementation benefits spinal cord health
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Study finds zinc effects on MS
We explored the effects of dietary zinc on spinal cord damage and the expression of certain genes linked to multiple sclerosis (MS) in a controlled study involving rat models. The study comprised 46 adult male Wistar rats, divided into five groups, including a control group and others subjected to cuprizone, which is known to induce MS-like symptoms.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Read More
8
Vidofludimus Calcium effective for RRMS
Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial.
Study focuses on RRMS treatment
In a carefully designed study, we examined the effectiveness of vidofludimus calcium in treating relapsing-remitting multiple sclerosis (RRMS). The trial involved a randomized, placebo-controlled approach where participants, aged 18 to 55 and experiencing active RRMS, were assigned to receive either vidofludimus calcium at doses of 30 mg, 45 mg, or a placebo. An additional group was later included to test a lower dose of 10 mg.
Over 24 weeks, we observed that both the 30 mg and 45 mg doses significantly reduced the formation of new brain lesions compared to the placebo. However, the lower 10 mg dose did not show the same effect, establishing that the minimum effective dose for this medication is 30 mg. Importantly, our findings support the notion that vidofludimus calcium can help manage disease activity in individuals with active RRMS.
While calcium plays a role in this treatment, our focus was primarily on the medication as a whole rather than isolating the effects of calcium itself. Therefore, although vidofludimus calcium demonstrated clear benefits, it doesn't allow us to draw conclusions about calcium alone.
Over 24 weeks, we observed that both the 30 mg and 45 mg doses significantly reduced the formation of new brain lesions compared to the placebo. However, the lower 10 mg dose did not show the same effect, establishing that the minimum effective dose for this medication is 30 mg. Importantly, our findings support the notion that vidofludimus calcium can help manage disease activity in individuals with active RRMS.
While calcium plays a role in this treatment, our focus was primarily on the medication as a whole rather than isolating the effects of calcium itself. Therefore, although vidofludimus calcium demonstrated clear benefits, it doesn't allow us to draw conclusions about calcium alone.
Read More
Most Useful Reviews
8.8
Notable improvement
Great product with good ingredients. I ordered it for my husband who has multiple sclerosis; he notices an improvement in the sensation in his hands and body when taking these. It's indeed a quality supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
Zinc supplementation benefits spinal cord health
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Study finds zinc effects on MS
We explored the effects of dietary zinc on spinal cord damage and the expression of certain genes linked to multiple sclerosis (MS) in a controlled study involving rat models. The study comprised 46 adult male Wistar rats, divided into five groups, including a control group and others subjected to cuprizone, which is known to induce MS-like symptoms.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Read More
8
Vidofludimus Calcium effective for RRMS
Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial.
Study focuses on RRMS treatment
In a carefully designed study, we examined the effectiveness of vidofludimus calcium in treating relapsing-remitting multiple sclerosis (RRMS). The trial involved a randomized, placebo-controlled approach where participants, aged 18 to 55 and experiencing active RRMS, were assigned to receive either vidofludimus calcium at doses of 30 mg, 45 mg, or a placebo. An additional group was later included to test a lower dose of 10 mg.
Over 24 weeks, we observed that both the 30 mg and 45 mg doses significantly reduced the formation of new brain lesions compared to the placebo. However, the lower 10 mg dose did not show the same effect, establishing that the minimum effective dose for this medication is 30 mg. Importantly, our findings support the notion that vidofludimus calcium can help manage disease activity in individuals with active RRMS.
While calcium plays a role in this treatment, our focus was primarily on the medication as a whole rather than isolating the effects of calcium itself. Therefore, although vidofludimus calcium demonstrated clear benefits, it doesn't allow us to draw conclusions about calcium alone.
Over 24 weeks, we observed that both the 30 mg and 45 mg doses significantly reduced the formation of new brain lesions compared to the placebo. However, the lower 10 mg dose did not show the same effect, establishing that the minimum effective dose for this medication is 30 mg. Importantly, our findings support the notion that vidofludimus calcium can help manage disease activity in individuals with active RRMS.
While calcium plays a role in this treatment, our focus was primarily on the medication as a whole rather than isolating the effects of calcium itself. Therefore, although vidofludimus calcium demonstrated clear benefits, it doesn't allow us to draw conclusions about calcium alone.
Read More
8
Magnesium biotin enhances remyelination
Dose-Dependent Effect of a New Biotin Compound in Hippocampal Remyelination in Rats.
Study assesses magnesium's MS effects
We investigated the potential benefits of magnesium in the form of a new compound, magnesium biotin (MgB), on remyelination in rats with induced demyelination. This is particularly relevant for conditions like multiple sclerosis (MS), where demyelination plays a critical role in disease progression. Through our study, we compared MgB's effects to those of standard biotin.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Read More
7
Zinc levels and MS correlation
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Highly relevant to MS treatment
We conducted a study to understand how zinc may affect multiple sclerosis (MS). Our research involved 98 participants, divided into two groups: one with MS and another matched control group without the condition. We aimed to examine the levels of zinc in both plasma and red blood cells to see if there’s a connection with MS severity and outbreaks.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
Read More
7
Zinc affects T cell function in MS
Ionic mitigation of CD4 T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Zinc treatment shows promise for MS
We explored how zinc, specifically zinc aspartate (UNIZINK), influences the immune system in the context of multiple sclerosis (MS). This study looked at zinc's effects on CD4 T cells, which play a significant role in autoimmune responses like those found in MS. Through transcriptomic analysis, we found that high doses of zinc negatively affect gene networks associated with cell cycle and energy metabolism in these T cells.
Particularly, in the presence of zinc, we observed reduced expression of vital genes involved in processes like glycolysis and oxidative phosphorylation, leading to decreased metabolic fitness and viability of the T cells. This inability to properly function might help explain why high zinc levels could prevent the differentiation of T cells into harmful Th1 cells, which are linked to MS inflammation in the central nervous system.
Moreover, the research showed that zinc treatment significantly reduced Th1 autoimmune inflammation in vivo and also impacted Th2-driven airway inflammation, suggesting a broader immunomodulatory role. Overall, while zinc treatment appears to offer some promise in reducing autoimmune responses associated with multiple sclerosis, more research is definitely needed to fully understand its capacity and effectiveness in clinical applications.
Particularly, in the presence of zinc, we observed reduced expression of vital genes involved in processes like glycolysis and oxidative phosphorylation, leading to decreased metabolic fitness and viability of the T cells. This inability to properly function might help explain why high zinc levels could prevent the differentiation of T cells into harmful Th1 cells, which are linked to MS inflammation in the central nervous system.
Moreover, the research showed that zinc treatment significantly reduced Th1 autoimmune inflammation in vivo and also impacted Th2-driven airway inflammation, suggesting a broader immunomodulatory role. Overall, while zinc treatment appears to offer some promise in reducing autoimmune responses associated with multiple sclerosis, more research is definitely needed to fully understand its capacity and effectiveness in clinical applications.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Notable improvement
Great product with good ingredients. I ordered it for my husband who has multiple sclerosis; he notices an improvement in the sensation in his hands and body when taking these. It's indeed a quality supplement.
